What is MAPT?

The MAPT gene encodes “microtubule-associated protein tau” which is expressed within the neurons in the brain. Mutations in the MAPT gene can exert several different effects on how this process functions. These differences in function can be unique to each specific mutation, but all result in the formation of aggregated tau inclusions, also known as tangles, which are theorized to drive neuronal loss and brain atrophy.

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Who we represent

We are a global community of families who have been impacted by MAPT FTD, often spanning multiple generations. Our group includes both individuals already diagnosed with FTD, positive MAPT carriers, and untested at 50% risk of carrying the genetic mutation.

Are you a foundation or donor who would like to support our efforts to create MAPT specific trials or gain entry into FTD/ALZ trials that have a TAU connection?

Does someone you love have the MAPT gene and you're looking for support and answers?

Have you or a loved one just been diagnosed with FTD and are looking for genetic counseling to discover if there is a genetic-component?

If the answer to any of these questions is yes, you're in the right place.

Our Mission

Awareness

Spread awareness of FTD, of the importance of genetic testing, and of Tau/MAPT.

Advocacy

Advocate for MAPT-specific trials and access to other FTD gene-specific trials.

Connection

Find, and connect to, the growing global network of MAPT families and researchers.

In the News

The Vanishing Family

In 2023, one of the founding families of Cure MAPT FTD was featured inarticle by award-winning journalist and New York Times-bestselling author, Robert Kolker.

Read the full story Listen to the NYT podcast

Featured Event

November 1, 2024

2:30 pm

EST

First Fridays: November 2024

Upcoming

This First Fridays meeting will focus on discussions within our group, including a breakout discussion between members where we can get to know each other better, and a discussion on an upcoming fundraising campaign.

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